Curriculum vitae

• Since Jan 2022: Associate Researcher at the Chair of Chemistry of Biogenic Resources

• 2016 – 2021: PhD student at the Theoretical Chemical Biology and Protein Modelling Group, Technical University of Munich (Prof. Dr. I. Antes)

• 2016: MSc thesis at Biotechnology and Enzyme Catalysis group, Greifswald University (Prof. Dr. UT. Bornscheuer)

• 2014-2016: MSc Drug Design and Safety, VU University Amsterdam – Graduated with Honors / Cum Laude

• 2011-2014: BSc Pharmaceutical Sciences, VU University Amsterdam – Graduated with Honors / Cum Laude

Research

• Computer-aided Drug and Enzyme Design
• Biomolecular Simulations
• Rational Protein and Enzyme Engineering

Publications

Melse, O.; Sutiono, S.; Haslbeck, M.; Schenk, G.; Antes, I.; Sieber, V.; Structure-Guided Modulation of the Catalytic Properties of [2Fe-2S]-Dependent Dehydratases, 9 March 2022, ChemBioChem.
DOI: 10.1002/cbic.202200088

Melse, O.; Hecht, S.; Antes, I.; DynaBiS: A hierarchical sampling algorithm to identify flexible binding sites for large ligands and peptides, Proteins: Struct. Funct. Bioinf. 2022, 90 (1), 18-32.
DOI: 10.1002/prot.26182

Pedroso, M. M.; Waite, D. W.; Melse, O.; Wilson, L.; Mitić, N.; McGeary, R. P.; Antes, I.; Guddat, L. W.; Hugenholtz, P.; Schenk, G., Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse. Protein & Cell 2020, 11 (8), 613-617. DOI: 10.1007/s13238-020-00736-4

Sikandar, A.; Franz, L.; Melse, O.; Antes, I.; Koehnke, J., Thiazoline-Specific Amidohydrolase
PurAH Is the Gatekeeper of Bottromycin Biosynthesis. J. Am. Chem. Soc. 2019, 141 (25), 9748-9752. DOI: 10.1021/jacs.8b12231

Schwarte, A.; Genz, M.; Skalden, L.; Nobili, A.; Vickers, C.; Melse, O.; Kuipers, R.; Joosten, H.-
J.; Stourac, J.; Bendl, J.; Black, J.; Haase, P.; Baakman, C.; Damborsky, J.; Bornscheuer, U.; Vriend, G.;
Venselaar, H., NewProt – a protein engineering portal. Protein Engineering, Design and Selection 2017, 30 (6), 441-447. DOI: 10.1093/protein/gzx024

Genz, M.; Melse, O.; Schmidt, S.; Vickers, C.; Dörr, M.; van den Bergh, T.; Joosten, H.-J.;
Bornscheuer, U. T., Engineering the Amine Transaminase from Vibrio fluvialis towards Branched-Chain Substrates. ChemCatChem 2016, 8 (20), 3199-3202. DOI: 10.1002/cctc.201601007