Curriculum

• Aug 2023 – Current: Postdoctoral Researcher at the Chair of Biogenic Resources, Technical University of Munich, Straubing, Germany
• May 2023 – Aug 2023: Postdoctoral Researcher at the School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
• Jan 2019 – May 2023: PhD in Biochemistry at the School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
  • PhD thesis title: Structure, function, and inhibition of Fe-S cluster-dependent dehydratases from the ilvD/EDD family
• Oct 2022 – May 2023: Senior Research Assistant at the Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia
• Jul 2014 – Nov 2018: Bachelor of Biotechnology Class I Honours at the School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
  • Honours thesis title: Inhibitors of KARI as anti-tuberculosis drug leads

Research

My research focuses on establishing one-pot multi-enzyme cascades to produce valuable chemical products from renewable feedstocks such as various sugars. The main focus is on the characterisation and optimisation of the various enzymes within these cell-free cascades. Improving the properties of the bottleneck enzymes for increased activity, substrate promiscuity, solvent tolerance and thermostability via enzyme engineering is vital to the success of these cell-free enzymatic cascades. Furthermore, improving the overall efficiency and yield of the multi-enzymatic systems is essential to become industrially applicable for sustainable production

Publications

1. Bayaraa, T. Lonhienne, S. Sutiono, O. Melse, T. B. Brück, E. Marcellin, P. V. Bernhardt, M. Boden, J. R. Harmer, V. Sieber, L. W. Guddat, G. Schenk, Structural and Functional Insight into the Mechanism of the Fe-S Cluster-Dependent Dehydratase from Paralcaligenes ureilyticus, Chemistry – A European Journal, Nov 2022
2. Bayaraa, J. Gaete, S. Sutiono, J. L. Kurz, T. Lonhienne, J. R. Harmer, P. V. Bernhardt, V. Sieber, L. W. Guddat, G. Schenk, Dihydroxy-Acid Dehydratases from Pathogenic Bacteria: Emerging Drug Targets to Combat Antibiotic resistance, Chemistry – A European Journal, May 2022
3. Bayaraa, J. L. Kurz, K. M. Patel, W. M. Hussein, J. K. Bilyj, N.P. West, G. Schenk, R. P. McGeary, L. W. Guddat, Discovery, Synthesis and Evaluation of a Ketol-Acid Reductoisomerase Inhibitor, Chemistry – A European Journal, Feb 2020