Curriculum

• Since 2021: Research associate at the Chair of Chemistry of Biogenic Resources, Technical University of Munich
• 2018-2021: PhD in Chemistry/Engineering at the University of Graz (Austria) and at the Aarhus University (Denmark) in the field of biocatalytic synthesis (Marie Skłodowska-Curie joint doctorate (PhotoBioCat–Light-driven sustainable Biocatalysis Training Network).
• PhD thesis: “Photo(bio)catalytic transformations employing light-dependent protochlorophyllide oxidoreductases and an unspecific peroxygenase.”
• 2018: Industrial secondment at GlaxoSmithKline (GSK) within the PhD, Stevenage, UK
• 2012-2017: Study of chemistry at the Philipps-Universität Marburg

Research:

• Chemoenzymatic synthesis: Conversion of biomass into valuable fine and bulk chemicals

• Biotransformations: Enzymatic reactions with NAD(P)H-derivatives

• Organic Synthesis: Synthesis of monomers, Synthesis of non-natural cofactors

Publications:

• Chromoselective Photocatalysis Enables Stereocomplementary Biocatalytic Pathways.

Schmermund, L.; Reischauer, S.; Bierbaumer, S.; Winkler, C. K.;Diaz-Rodriguez, A.; Edwards, L. J; Kara, S.; Mielke, T.; Cartwright, J.; Grogan, G.; Pieber, B; Kroutil W., Angew. Chem. Int. Ed. 2021, 60, 6965-6969, https://doi.org/10.1002/anie.202100164.

• A Robust and Stereocomplementary Panel of Ene-Reductase Variants for gram-Scale Asymmetric Hydrogenation.

Nett, N.; Duewel, S.; Schmermund, L.; Benary, G. E.; Ranaghan, K.; Mulholland, A.; Opperman, D. J.; Hoebenreich, S., Mol. Catal. 2021, 502, 111404, https://doi.org/10.1016/j.mcat.2021.111404.

• Directed Evolution of an FeII-Dependent Halogenase for Asymmetric C(sp³)−H Chlorination. Duewel, S.; Schmermund, L.; Faber, T.; Harms, K.; Srinivasan, V.; Meggers, E.; Hoebenreich S., ACS Catal. 2020, 10, 1272-1277, https://doi.org/10.1021/acscatal.9b04691.

• Extending the Library of Light‐Dependent Protochlorophyllide Oxidoreductases and their Solvent Tolerance, Stability in Light and Cofactor Flexibility.

Schmermund, L.; Bierbaumer, S.; Schein, V. K.; Winkler, C. K.; Kara, S; Kroutil, W., ChemCatChem 2020, 12, 4044-4051, https://doi.org/10.1002/cctc.202000561.

• Photo-Biocatalysis: Biotransformations in the Presence of Light.

Schmermund, L.; Jurkaš, V.; Özgen, F. F.; Barone, G. D.; Büchsenschütz, H. C.; Winkler, C. K.; Schmidt, S.; Kourist, R.; Kroutil, W., ACS Catal. 2019, 9, 4115-4144, https://doi.org/10.1021/acscatal.9b00656.

• Chemoenzymatic Total Synthesis of Deoxy‐, epi‐, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones.

Lazzarotto, M.; Hammerer, L.; Hetmann, M.; Borg, A.; Schmermund, L.; Steiner, L.; Hartmann, P.; Belaj, F.; Kroutil, W.; Gruber, K.; Fuchs, M., Angew. Chem. Int. Ed. 2019, 58, 8226-8230, https://doi.org/10.1002/anie.201900926.

• The Right Light: De Novo Design of a Robust Modular Photochemical Reactor for Optimum Batch and Flow Chemistry.

Bonfield, H. E.; Mercer, K.; Diaz-Rodriguez, A.; Cook, G. C.; McKay, B. S. J., Slade, P.; Taylor, G. M.; Xiang Ooi, W., Williams, J. D.; Roberts, J. P. M.; Murphy, J. A.; Schmermund, L.; Kroutil, W.; Mielke, T.; Cartwright, J.; Grogan, G.; Edwards, L. J., ChemPhotoChem 2019, 4, 45-51, https://doi.org/10.1002/cptc.201900203.